When was sudafed created

Pseudoephedrine has a pregnancy category of B. Pseudoephedrine is excreted in breast milk in small amounts. Fully breast-fed infants whose mothers took a full mg dose of pseudoephedrine would receive between 2. The most significant adverse reaction to taking pseudoephedrine while breast-feeding is a decrease in milk production. A single dose of pseudoephedrine can significantly reduce milk production, and continued use could upset lactation, 9 hence its off-label use for hyperprolactinemia.

Oral forms of pseudoephedrine are readily absorbed from the gastrointestinal tract and excreted principally unchanged in the urine. A small amount is metabolized in the liver and also excreted in the urine. The half-life of pseudoephedrine is between 5 and 8 hours, though the more acidic the urine, the lower the half-life.

Pseudoephedrine can be illegally used to manufacture methamphetamine, which has become a national epidemic. This law bans over-the-counter sales of medications containing pseudoephedrine, so these products must be sold from locked cabinets or behind the pharmacy counter.

The law also limits the amount of pseudoephedrine that a person can purchase daily 3. Check with your state board for clarification. Since the implementation of the Combat Methamphetamine Epidemic Act, it has been difficult to obtain pseudoephedrine for the general public, but the methamphetamine epidemic has just continued to grow.

The name is a reference to the active ingredient , pseudoephedrine hydrochloride , traditionally associated with the product; but, because of, legal restrictions on the sale of pseudoephedrine recently imposed in many markets, some products sold under the Sudafed brand name do not contain any form of pseudoephedrine.

In late , Pfizer started publicly disclosing its plans to make available a new OTC product, Sudafed PE, which does not include pseudoephedrine. Sudafed PE contains a different decongestant called phenylephrine , in a formulation sold for years. Decongestants with other ingredients will be completely converted to phenylephrine later in , though original Sudafed will still be offered.

The new product was prompted by existing and proposed restrictions on the availability of pseudoephedrine-based products. State laws imposing such restrictions were in response to pseudoephedrine's role as an ingredient used to produce the illegal and highly addictive stimulant methamphetamine , also known as crystal meth. Pfizer and its predecessor Warner-Lambert had studied at least two alternatives to its current formula in anticipation of pressure from state regulators and the Food and Drug Administration :.

The Act would ban over-the-counter sales of cold medicines that contain ingredients that are commonly used to make methamphetamine such as pseudoephedrine. Pseudoephedrine is a drug found in both prescription and over-the-counter products used to relieve nasal or sinus congestion caused by the common cold, sinusitis, hay fever, and other respiratory allergies.

It can also be used illegally to produce methamphetamine. Methamphetamine is a powerful, highly addictive stimulant. It is manufactured in covert, illegal laboratories throughout the United States. Methamphetamine can be ingested by swallowing, inhaling, injecting or smoking. The side effects, which arise from the use and abuse of methamphetamine, include irritability, nervousness, insomnia, nausea, depression, and brain damage.

Methamphetamine Fact Sheet from the U. Drug Enforcement Administration. The Act allows for the sale of pseudoephedrine only from locked cabinets or behind the counter. The law:. Does the requirements of this law affect combination products, or just products that contain pure pseudoephedrine? The requirements of this law will affect all products that contain ingredients pseudoephedrine, phenylpropanolamine, and ephedrine. Find Out More. Careers Launch and grow your career with career services and resources.

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What molecule am I? What does pseudoephedrine do, and what are its downsides? The good: Pseudoephedrine is an effective nasal and sinus decongestant.